COVID vaccine update

Anyone can read this board. However, to post messages, you must register.
Post Reply
AO Sig
Regent's Circle
Posts: 8097
Joined: Wed Jun 30, 2004 5:42 am
Location: Kingsport, Tennessee

COVID vaccine update

Post by AO Sig »

I hope that I am not being too presumptuous or arrogant, but since a few of y''all gave been interested in any information on the vaccines, I thought that I would start a thread to discuss this topic. Why on the athletics? Because the development of multiple, effective vaccines will give us the best chance at our meeting up in the stands at future sports events, and will put an end to the sporting events being cancelled due to positive tests. If the teams can get vaccinated, the transmission rate drops big-time. It is not going to cure this; it will, however, reduce the rate of transmission and hopefully get us back to more normal lives.

Anyway, I saw an article on a Boston Dr. announcing that he had "allergic reactions" to the Moderna vaccine; one of my pet peeves is the use of the term "allergic reaction." A true allergic reaction results in swelling in the throat, tongue, etc. It is not a little headache, feverishness, soreness at the site, nausea. If you have seen the Martin Short-Danny Glover film, "Pure Luck," there is a scene when Short swells up after a bee sting; that is an example, albeit a bit overexaggerated, of a true allergic reaction. I saw a comment by an allergist, who concurred that it was not a true allergic reaction. He also raised the question of whether a "cork sucker" of benadryl and steroids, which is used in people who have had a reaction to contrast dye, but needs a test done that includes one. I cannot guarantee that this would definitively prevent adverse events, I don't think it would hurt.

I had mild arm soreness near the injection site the next day; otherwise I had no problems with the Pfizer vaccine. My wife had a bit more arm pain than I did; she commented to me that she has had a lot less problems with this vaccine than she has in the past with the flu shot. Every vaccine has potential side effects; I saw another article this morning that the FDA is investigating 6 reports of major problems in people receiving the Pfizer vaccine; considering that over a million doses have probably been administered by now, that is a pretty safe vaccine.

BTW- anything I post will be a combination of information I have read, plus my opinions; I can guarantee that there are a ton of different opinions on everything, and I try to make comments based on my interpretation of the data and the stuff I learned over the years in the topics of immunology. We call it the "art of medicine," because it is not always precise; recommendations are made more often on a consensus than etched in stone. All one needs to do is look at how things have changed with the current pandemic; first masks were said to be of no value, now there is a battle to come up with the most fashionable ones.

The vaccine is just one part of the solution. Things to help stop transmission- washing hands, masks, social distancing- are all other steps to reducing transmission. The 90+% effectiveness we are seeing with these is amazing; to put this in perspective we push flu vaccines with the understanding that they might be only 50% effective. My daughter's 21st birthday is in Mid February; my vaccinations will improve my chances of staying well when surrounded by people who don't seem to care about their potential to infect others around them when I visit her in Orlando.
What if the Hokey Pokey really is what it's all about?
User avatar
Cheerleader
Coach Level
Posts: 2159
Joined: Wed Jun 30, 2004 11:22 am
Location: Destin, FL

Re: COVID vaccine update

Post by Cheerleader »

Thanks. My brother just came from his physical and he is fine, tested negative, but he has done some travel lately, so he asked his doctor what should he do if he gets sick while on travel. His doctor told him to immediately go to an ER and get a test done. If he is positive, call him and he will prescribe Regeneron and the other antibody medicine they gave Trump. He says take it right away and his symptoms will go away in a day or so. Do not wait for serveral days because the medicine won't work then. Is that good advice?
AO Sig
Regent's Circle
Posts: 8097
Joined: Wed Jun 30, 2004 5:42 am
Location: Kingsport, Tennessee

Re: COVID vaccine update

Post by AO Sig »

I think that this is reasonable from what I have read; I think that if the symptoms are such that oxygen levels are starting to drop, then the Regeneron combo is certainly reasonable. This disease has a lot of different levels of severity; my partner had some nasal stuffiness and mild cough, she decided to get tested on the side of caution, and the rapid test was positive. Subsequently her tween daughter and parents were tested, and all were positive. The daughter had no symptoms at all. Mom had mild respiratory symptoms. Dad had more shortness of breath, but did well on a little decadron and azithromycin (he has some other health issues, was on medications to err on the side of caution). None of theme came close to needing hospitalization, and so the cork sucker was not felt to be needed.

If a family member started to see a drop in the oxygen saturations, then I would quickly push for the regeneron product. One device that would be a reasonable purchase if you have any health issues (COPD, heart disease, metabolic synodrome- diabetes, hypertension and being overweight) is a small pulse-oximeter. It is the little doodad that you put on a finger, and it measures your oxygen saturation. Normal on room temperature is around 97-98; if you are feeling a little short of breath and the oxygen levels dip below 96, then it might be time to strongly consider pushing for more aggressive treatments. The pulse oximeter isn't very expensive; lots of choices on Amazon for 20-35 bucks.
Last edited by AO Sig on Thu Dec 31, 2020 11:54 am, edited 1 time in total.
What if the Hokey Pokey really is what it's all about?
AO Sig
Regent's Circle
Posts: 8097
Joined: Wed Jun 30, 2004 5:42 am
Location: Kingsport, Tennessee

Re: COVID vaccine update

Post by AO Sig »

How in the world does the term "c0cktail" get changed into cork-sucker?
What if the Hokey Pokey really is what it's all about?
User avatar
TUPF
Emerald Circle
Posts: 21061
Joined: Fri Jun 25, 2004 11:36 am
Location: Maryland Eastern Shore & sometimes Philly

Re: COVID vaccine update

Post by TUPF »

AO Sig, I've had that very discussion about "allergic reaction" with folks. I call what they describe as a sensitivity.

When I was stung by a wasp while stacking wood years ago on a Saturday my feet immediately started itching so profusely that I tore my socks getting them off and started sweating in buckets. I went inside and turned on the bathroom light and scared myself. I no longer had a neck--more like a bullfrog in full throated "ribbit". In my case the Martin Short character was no exaggeration. I could barely see out of my eyes and was starting to wheeze. I called my wife and when she saw me she screamed. Unfortunately we lived in rural Connecticut at the time so by the time we got to the SUBASE New London gate I was unconscious. My wife said the Marines radioed the hospital ER and she had an escort. She said that as they put me on a gurney and my wife explained what happened, the ER doctor said "wow, I learned about this in med school but this is the first time seeing it." Raised hives all over my body--I looked like a boiled lobster. I spent the night in ICU loaded up with IV meds and my symptoms finally abated. They released me home Sunday morning. However, almost 24 hours after the initial sting my symptoms started all over again. I called the ER and the same doctor was on duty and he ordered me to get back to the ER immediately. More IVs and several hours later I was released again loaded up with a week course of steroids.

Doc said whenever I fill out medical forms to be sure to put "full blown anaphylaxis from insect sting" and not allergy because folks claim allergy so much that it doesn't mean anything. Most doctors haven't even seen life threatening anaphylaxis. I've been stung twice since then by ground hornets with similar but not as severe immediate symptoms and because of that I pay someone else to do yard work. I have an EpiPen but my doctors have said to inject myself on the way to the ER.

When I heard that the vaccines may have affected a handful with a history of non-vaccine related anaphylaxis my ears perked up. I think I have one of those immune systems that is spoiling for a fight. I also think me getting COVID itself may cause the cytokine storm others have talked about and it would not go well. So I'm monitoring the literature (and thank you for your real time updates) but I fully intend to be vaccinated, in a hospital setting, with the big adrenaline guns at the ready when it's my turn.

And I got a highly rated pulse oximeter in my Christmas stocking for $27. :-D
Last edited by TUPF on Thu Dec 31, 2020 1:42 pm, edited 1 time in total.
After you've been on fire under Arctic pack ice everything else is a walk in the park.
User avatar
TUPF
Emerald Circle
Posts: 21061
Joined: Fri Jun 25, 2004 11:36 am
Location: Maryland Eastern Shore & sometimes Philly

Re: COVID vaccine update

Post by TUPF »

A good friend who is an ER charge nurse in Orange County, California told me this week that a consistent O2 level <92% is of concern and figures in the calculus for admission.
After you've been on fire under Arctic pack ice everything else is a walk in the park.
User avatar
PeteRasche
Emerald Circle
Posts: 24681
Joined: Wed Jul 20, 2005 11:52 am
Location: Cincinnati, OH

Re: COVID vaccine update

Post by PeteRasche »

AO Sig wrote: Thu Dec 31, 2020 11:51 am This disease has a lot of different levels of severity; my partner had some nasal stuffiness and mild cough, she decided to get tested on the side of caution, and the rapid test was positive. Subsequently her tween daughter and parents were tested, and all were positive. The daughter had no symptoms at all. Mom had mild respiratory symptoms. Dad had more shortness of breath, but did well on a little decadron and azithromycin (he has some other health issues, was on medications to err on the side of caution). None of theme came close to needing hospitalization...
My son's (3rd grade) teacher is an overweight man with bad eating habits and probably has underlying conditions because of it. He has a kid who graduated high school this past Spring another in high school now. His wife was slightly overweight (but not more than maybe the "average" person?) and had no other underlying issues. Last May, as the national lockdown/quarantine was dragging on and many people were "over it", the whole family attended an on-the-down-low graduation party. The entire family ended up with COVID-19 (apparently quite a few others at the party came down with it as well). The teacher, despite his conditions, had no symptoms; both kids had no symptoms. They buried the mom this past September after her lungs filled with fluid and blood clots that were not treatable with any of the various treatments. Now the surviving three have a lifetime of knowing they killed mom because they willingly decided their kid's party was more important than staying safe.

The one thing for certain with this disease is that nothing is for certain with this disease.
AO Sig
Regent's Circle
Posts: 8097
Joined: Wed Jun 30, 2004 5:42 am
Location: Kingsport, Tennessee

Re: COVID vaccine update

Post by AO Sig »

TUPF wrote: Thu Dec 31, 2020 1:38 pm AO Sig, I've had that very discussion about "allergic reaction" with folks. I call what they describe as a sensitivity.

When I was stung by a wasp while stacking wood years ago on a Saturday my feet immediately started itching so profusely that I tore my socks getting them off and started sweating in buckets. I went inside and turned on the bathroom light and scared myself. I no longer had a neck--more like a bullfrog in full throated "ribbit". In my case the Martin Short character was no exaggeration. I could barely see out of my eyes and was starting to wheeze. I called my wife and when she saw me she screamed. Unfortunately we lived in rural Connecticut at the time so by the time we got to the SUBASE New London gate I was unconscious. My wife said the Marines radioed the hospital ER and she had an escort. She said that as they put me on a gurney and my wife explained what happened, the ER doctor said "wow, I learned about this in med school but this is the first time seeing it." Raised hives all over my body--I looked like a boiled lobster. I spent the night in ICU loaded up with IV meds and my symptoms finally abated. They released me home Sunday morning. However, almost 24 hours after the initial sting my symptoms started all over again. I called the ER and the same doctor was on duty and he ordered me to get back to the ER immediately. More IVs and several hours later I was released again loaded up with a week course of steroids.

Doc said whenever I fill out medical forms to be sure to put "full blown anaphylaxis from insect sting" and not allergy because folks claim allergy so much that it doesn't mean anything. Most doctors haven't even seen life threatening anaphylaxis. I've been stung twice since then by ground hornets with similar but not as severe immediate symptoms and because of that I pay someone else to do yard work. I have an EpiPen but my doctors have said to inject myself on the way to the ER.

When I heard that the vaccines may have affected a handful with a history of non-vaccine related anaphylaxis my ears perked up. I think I have one of those immune systems that is spoiling for a fight. I also think me getting COVID itself may cause the cytokine storm others have talked about and it would not go well. So I'm monitoring the literature (and thank you for your real time updates) but I fully intend to be vaccinated, in a hospital setting, with the big adrenaline guns at the ready when it's my turn.

And I got a highly rated pulse oximeter in my Christmas stocking for $27. :-D
when I got my injection there was a triage as to whether there was significant risk of a hypersensitivity reaction. They screened me for likelihood of reaction, and based on my answers had to sit for observation for 15 minutes after receiving the vaccine. While some were assigned 0 minutes (presumably people getting their second dose), others were assigned 30 minutes. There was a crash cart in the room were I was assigned to "chill out;" You would be someone I would probably premedicate and watch a while.
What if the Hokey Pokey really is what it's all about?
User avatar
TUPF
Emerald Circle
Posts: 21061
Joined: Fri Jun 25, 2004 11:36 am
Location: Maryland Eastern Shore & sometimes Philly

Re: COVID vaccine update

Post by TUPF »

Ya think? :lol: :lol: :lol:

I'll pack a lunch.
After you've been on fire under Arctic pack ice everything else is a walk in the park.
doc
Coach Level
Posts: 1971
Joined: Sat Jun 26, 2004 11:05 pm

Re: COVID vaccine update

Post by doc »

Thank you so much for the updates -- keep them coming -- I just ordered my pulse oximeter
AO Sig
Regent's Circle
Posts: 8097
Joined: Wed Jun 30, 2004 5:42 am
Location: Kingsport, Tennessee

Re: COVID vaccine update

Post by AO Sig »

I just saw this in one of my AMA updates; answers questions about the Pfizer vaccine. Based on the fact that the Moderna is very similar, I would say that the same information pertains to it. The issue of vaccine allergy is a big component, so those of you who have had a reaction to a vaccine might want to avoid these unless given a ton of pretreatment.

https://www.ama-assn.org/delivering-car ... ds_weekend
What if the Hokey Pokey really is what it's all about?
User avatar
WaveProf
Emerald Circle
Posts: 22831
Joined: Sun Sep 13, 2009 12:45 pm
Location: Irish Channel, New Orleans

Re: COVID vaccine update

Post by WaveProf »

AO Sig, curious if you have any idea if states mean higher ed teachers as well when they say "teachers", or solely K-12?
“We will expect success in all endeavors and be prepared to assess and hold ourselves accountable when we aren't successful. Tulane is a top 40 academic institution and it should expect nothing less from its athletic department.” --Troy Dannen 11.5.16
User avatar
Private Joker
Navigator Level
Posts: 1408
Joined: Thu Aug 26, 2004 3:50 pm
Location: Bainbridge Island USA

Re: COVID vaccine update

Post by Private Joker »

I've been on two airplane rides since COVID started: to New Orleans in August, and to Arizona 10 days ago. After seeing that 41-year old congressman-elect die a couple of days ago, I'm not going anywhere until this thing is over. Better to not see relatives for a while now, and get to see them for the next 20 years . . .
AO Sig
Regent's Circle
Posts: 8097
Joined: Wed Jun 30, 2004 5:42 am
Location: Kingsport, Tennessee

Re: COVID vaccine update

Post by AO Sig »

WaveProf wrote: Sat Jan 02, 2021 12:57 pm AO Sig, curious if you have any idea if states mean higher ed teachers as well when they say "teachers", or solely K-12?
I suspect that they are meaning the K-12 instructors, but if you can probably try to get in line when they open up to teachers as "essential workers," since the supply of vaccines seems to be such that they can already get to the tier 1-a-2 people in most areas. In our area 1-a-1 were the hospital people who come in contact with COVID patients; my office qualifies as 1-a-2 in Tennessee, which includes primary care people and specialists who deal with patients at increased risk because of their diseases and treatments, such as oncology and rheumatology. It also lists mortuary workers who can come in contact with decedents. Nursing home patients are also high on the list.

My thoughts are if you can show proof of being a teacher when they start giving it to that level, I'd say go for it.
What if the Hokey Pokey really is what it's all about?
User avatar
Roller
Cornerstone
Posts: 33016
Joined: Sat Jun 19, 2004 7:30 pm
Location: 30°37'40.6"N 81°27'02.4"W

Re: COVID vaccine update

Post by Roller »

Mike Rowe says that college teachers are unnecessary.
:wink:
User avatar
PeteRasche
Emerald Circle
Posts: 24681
Joined: Wed Jul 20, 2005 11:52 am
Location: Cincinnati, OH

Re: COVID vaccine update

Post by PeteRasche »

Private Joker wrote: Sat Jan 02, 2021 1:27 pm I've been on two airplane rides since COVID started: to New Orleans in August, and to Arizona 10 days ago. After seeing that 41-year old congressman-elect die a couple of days ago, I'm not going anywhere until this thing is over. Better to not see relatives for a while now, and get to see them for the next 20 years . . .
351,000 other deaths weren't enough, that one guy convinced you ?
User avatar
Cheerleader
Coach Level
Posts: 2159
Joined: Wed Jun 30, 2004 11:22 am
Location: Destin, FL

Re: COVID vaccine update

Post by Cheerleader »

PeteRasche wrote: Sun Jan 03, 2021 10:30 pm
Private Joker wrote: Sat Jan 02, 2021 1:27 pm I've been on two airplane rides since COVID started: to New Orleans in August, and to Arizona 10 days ago. After seeing that 41-year old congressman-elect die a couple of days ago, I'm not going anywhere until this thing is over. Better to not see relatives for a while now, and get to see them for the next 20 years . . .
351,000 other deaths weren't enough, that one guy convinced you ?
He had a heart attack "during a Covid procedure"....what does that mean? Were they stuffing a ventilator down his throat?
User avatar
Private Joker
Navigator Level
Posts: 1408
Joined: Thu Aug 26, 2004 3:50 pm
Location: Bainbridge Island USA

Re: COVID vaccine update

Post by Private Joker »

PeteRasche wrote: Sun Jan 03, 2021 10:30 pm
Private Joker wrote: Sat Jan 02, 2021 1:27 pm I've been on two airplane rides since COVID started: to New Orleans in August, and to Arizona 10 days ago. After seeing that 41-year old congressman-elect die a couple of days ago, I'm not going anywhere until this thing is over. Better to not see relatives for a while now, and get to see them for the next 20 years . . .
351,000 other deaths weren't enough, that one guy convinced you ?
Yes, because that 351K were either very old or had something else wrong with them. And apart from those two trips I've been hunkered down. No parties, no friends, very limited eating out.
User avatar
TUPF
Emerald Circle
Posts: 21061
Joined: Fri Jun 25, 2004 11:36 am
Location: Maryland Eastern Shore & sometimes Philly

Re: COVID vaccine update

Post by TUPF »

Private Joker wrote: Mon Jan 04, 2021 1:18 am
PeteRasche wrote: Sun Jan 03, 2021 10:30 pm
Private Joker wrote: Sat Jan 02, 2021 1:27 pm I've been on two airplane rides since COVID started: to New Orleans in August, and to Arizona 10 days ago. After seeing that 41-year old congressman-elect die a couple of days ago, I'm not going anywhere until this thing is over. Better to not see relatives for a while now, and get to see them for the next 20 years . . .
351,000 other deaths weren't enough, that one guy convinced you ?
Yes, because that 351K were either very old or had something else wrong with them. And apart from those two trips I've been hunkered down. No parties, no friends, very limited eating out.
Here's the thing about this virus. It doesn't matter that one had that "one slip", had to see my grandchild that one time, shared that one drink, had that one meal out, flew that one time.

My daughter and her entire family spent the last two weeks in bed which included a Christmas Eve in the ER with the dad, age 46 and in perfect health beforehand, the sickest he has ever been in his life. He has lost 30 pounds and looks terrible. Mom can't smell or taste. Both spike fevers constantly. How did this happen? They were "done with COVID" and when their posh private school in the Dallas Metroplex offered the choice of in school or at home school they chose in school. I'd see pictures of the 14 YO without mask with his friends. He's on the 8th grade basketball team which has regular games. What happened next was predictable. A classmate got COVID and so did the son who promptly brought it home and infected the whole family. His symptoms were relatively mild but Mom and especially Dad had a hellish last two weeks. Fortunately they have a good support network delivering food on the front porch.

There are plenty dead who weren't old, fat, diabetic, or had COPD. But if we are being honest, compromised health Americans describes a large part of our population. Either way you take your chances. It's a hockey game with 1000 shots on goal and all it takes is one.
After you've been on fire under Arctic pack ice everything else is a walk in the park.
gerryb323
Regent's Circle
Posts: 7510
Joined: Thu Jul 01, 2010 11:18 am
Location: We're not in Kansas anymore

Re: COVID vaccine update

Post by gerryb323 »

TUPF wrote: Mon Jan 04, 2021 9:27 am
Private Joker wrote: Mon Jan 04, 2021 1:18 am
PeteRasche wrote: Sun Jan 03, 2021 10:30 pm
Private Joker wrote: Sat Jan 02, 2021 1:27 pm I've been on two airplane rides since COVID started: to New Orleans in August, and to Arizona 10 days ago. After seeing that 41-year old congressman-elect die a couple of days ago, I'm not going anywhere until this thing is over. Better to not see relatives for a while now, and get to see them for the next 20 years . . .
351,000 other deaths weren't enough, that one guy convinced you ?
Yes, because that 351K were either very old or had something else wrong with them. And apart from those two trips I've been hunkered down. No parties, no friends, very limited eating out.
Here's the thing about this virus. It doesn't matter that one had that "one slip", had to see my grandchild that one time, shared that one drink, had that one meal out, flew that one time.

My daughter and her entire family spent the last two weeks in bed which included a Christmas Eve in the ER with the dad, age 46 and in perfect health beforehand, the sickest he has ever been in his life. He has lost 30 pounds and looks terrible. Mom can't smell or taste. Both spike fevers constantly. How did this happen? They were "done with COVID" and when their posh private school in the Dallas Metroplex offered the choice of in school or at home school they chose in school. I'd see pictures of the 14 YO without mask with his friends. He's on the 8th grade basketball team which has regular games. What happened next was predictable. A classmate got COVID and so did the son who promptly brought it home and infected the whole family. His symptoms were relatively mild but Mom and especially Dad had a hellish last two weeks. Fortunately they have a good support network delivering food on the front porch.

There are plenty dead who weren't old, fat, diabetic, or had COPD. But if we are being honest, compromised health Americans describes a large part of our population. Either way you take your chances. It's a hockey game with 1000 shots on goal and all it takes is one.
I can't believe we're still having this argument. Oh wait, yes I can
hashtagStopbunting
hashtagStopPUNTING!
User avatar
PeteRasche
Emerald Circle
Posts: 24681
Joined: Wed Jul 20, 2005 11:52 am
Location: Cincinnati, OH

Re: COVID vaccine update

Post by PeteRasche »

Private Joker wrote: Mon Jan 04, 2021 1:18 am
PeteRasche wrote: Sun Jan 03, 2021 10:30 pm351,000 other deaths weren't enough, that one guy convinced you ?
Yes, because that 351K were either very old or had something else wrong with them. And apart from those two trips I've been hunkered down. No parties, no friends, very limited eating out.
If you really think this guy was the first person who was healthy and had no underlying conditions out of 351,000 deaths, then you need to change your news source. Actually, you need to follow the posts and blogs of virologists and epidemiologists and NOT follow any "news" source whatsoever. The selectivity of the information that the public has been fed by BOTH sides is disgusting.
NJwave
Regent's Circle
Posts: 5244
Joined: Tue Jan 06, 2015 8:18 pm

Re: COVID vaccine update

Post by NJwave »

I know several people that have died of COVID, several that have been severely sick and some that were lucky and had very little symptoms. Some were elderly, some had severe underlying conditions and some were young and healthy. Do we really have to convince Tulane people the severity of this virus all these months later?
User avatar
TUPF
Emerald Circle
Posts: 21061
Joined: Fri Jun 25, 2004 11:36 am
Location: Maryland Eastern Shore & sometimes Philly

Re: COVID vaccine update

Post by TUPF »

NJwave wrote: Mon Jan 04, 2021 1:21 pm I know several people that have died of COVID, several that have been severely sick and some that were lucky and had very little symptoms. Some were elderly, some had severe underlying conditions and some were young and healthy. Do we really have to convince Tulane people the severity of this virus all these months later?
"Rounding the corner" to 360,000 Americans in body bags says yes.
After you've been on fire under Arctic pack ice everything else is a walk in the park.
User avatar
PeteRasche
Emerald Circle
Posts: 24681
Joined: Wed Jul 20, 2005 11:52 am
Location: Cincinnati, OH

Re: COVID vaccine update

Post by PeteRasche »

NJwave wrote: Mon Jan 04, 2021 1:21 pmDo we really have to convince Tulane people the severity of this virus all these months later?
Yes because half the country has been told it's fake news.
User avatar
Roller
Cornerstone
Posts: 33016
Joined: Sat Jun 19, 2004 7:30 pm
Location: 30°37'40.6"N 81°27'02.4"W

Re: COVID vaccine update

Post by Roller »

PeteRasche wrote: Mon Jan 04, 2021 3:14 pm
NJwave wrote: Mon Jan 04, 2021 1:21 pmDo we really have to convince Tulane people the severity of this virus all these months later?
Yes because half the country has been told it's fake news.
And because "credible" sources keep reporting diametrically opposite statistics. And sometimes, those conflicting "sources" are the same person! (e.g., Anthony Fauci)
Post Reply